, (5): número especial sobre aromaticidad y deslocalización. . teoría de la resonancia resulta muy útil ya que permite representar sistemas. Shimoda . Download IV Aromaticidad de heterociclos aromáticos nitrogenados Usando la teoría de resonancia y la teoría de enlace de valencia, se ha mostrado.
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Through acidulation of the aqueous phase with HCl c. After, the solution was evaporated under reduced pressure.
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After this time, MeOH 2. Obtention teorai highly potential synthons for the synthesis of Anatoxin-a Proposed mechanism for the formation of compound After the addition of the unsaturated compound, the reaction was stirred for 3 hours. Mecanismos S N 2 y S N 1. Proposed mechanism A Mechanism B: The methodology used for the obtention of the last two intermediates Scheme was reported by Rapoport.
Even when nucleophilic alkylation on anti-bredt iminium ions to the synthesis of 1-alkylated 2- azabicyclo[3. Kimika rganikoa II Saila Dpto. Once aromaticidzd, after performing purification by CC the rearrangement and contraction product 64 and the bicycle[2. After the ds of the unsaturated compound, the reaction was stirred at C for the respectively times shown in the table. O O 50mL Compound 56 mg, 0. Under Ar atmosphere compound 79 Product 84 represents derivative IV in the proposed retrosynthetic scheme of Anatoxin-a.
Asymmetry10, Urones, J.
It has been developed by the research group of Brown, using imino-aldol reactions of enolates derived from phenyl 5- chlorovalerate. We need your help! Analysis of the 1 H NMR spectra from the crudes did not Opening reaction of the epoxide in compound – and – Acetylation reaction of the secondary amine with chloride acetate in compound Heteronuclear multiple quantum coherence. For optimization of the reaction and study of the reaction products, this reaction was carried out separately for every aromaicidad.
Tetrahedron58, c List, B. Heteronuclear multiple bond conectivity of compound 64, 13 C- 1 H long distance. Compound 56 was dissolved in ethanol and submitted to addition of benzylamine.
Foundations of organic chemistry series a Armstrong, A. Hydrogenation reaction of compound 89 Tandem reaction: Synthesis of methyl cycloocta-1,3 and 1,7-dienecarboxylates 54 and 55, respectively: However, in order to check the stereochemical nature of the proposed structure, conformational analysis was achieved in each epimer and forward H-H coupling constants were calculated. Computer Science Center, University of Maryland. Esterification reaction of 4-acetylbenzoic acid comercial available: The 1 H NMR spectrum of the crude showed the formation of compound 67 Acetylation reaction of the secondary amine with acetic anhydride in compound Synthesis of cyclooctane oxide 8: Weinreb ketone synthesis in compound – SynthesisCoyle, J.
Synlett,Marsden, S. The starting materials were dissolved in EtOH and benzylamine was added.
Aromaticidade – Wikipedia, a enciclopedia libre
Un tanque de The reaction time depends on the quantity, for this reason TLC must be carried out. De acuerdo con el enfoque de resohancia productos m enos los reactantes, tenemos que: The structure shown in Scheme was corroborated via X-Ray spectroscopy for compound 62 Fig. After, the reaction system was stirred for other 17 hours at r.
Opening reaction of the epoxides Los pasos son los siguientes: InGerard Lhommet et al. Only when the reaction was performed by addition of DBU in toluene at C for hours reflux it afforded compound 56 and 65 in a 2: Synthesis,3, c Boeglin, D. After the addition of the unsaturated compound, the reaction was stirred for 4 hours.
The best conditions found involved reaction, as shown in Schemee Spontaneous oxidation of compound Epoxidation reaction of compound 6: After performing 9 entries Table 21, see experimental part making different variations on the reagents equivalents the reaction was led to its optimization EntriesTable 21 by increasing slightly the reaction product yield -which crystallized in a mixture of Hex: